When I first played Pokemon red and it took me ages to figure out how to leave my house, and then after that I didn't know how to save and I had a Ivysaur and I just turned it off D:
The time on Pokemon Blue where I stayed in Veridian Forest, training my Charmender to Charmeleon, and into Charizard, all before fighting Brock.
In Brawl, Lucario (me) was leaping off Smashville to deliver the finishing touches on Mario. When suddenly a Bob-omb appeared over me just as I was attacking. My damage was at 117% so...
You lucked out plumber boy....
Here's a REAL low point. In Mario Kart DS I was racing online with someone from Brazil, Japan and England. I was about to win the race (behind me the Japanese racer, then the English...) when suddenly out of nowhere, I sneeze. Didn't feel it coming, had no waring then BOOM. I jerk a bit, and when I open my eyes again (since the designers of the human race made it impossible to keep your eyes open when you sneeze) I'm in 4th. Looking at the replay, it looked like I just drove off to the side to allow the other guys (or girls) to win.
...I haven't played in months.